

Coffee and caffeine consumption and depression: A meta-analysis of observational studies. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Cafestol, a bioactive substance in coffee, has antidiabetic properties in KKAY mice. Systematic review with meta‐analysis: Coffee consumption and the risk of cirrhosis. Coffee consumption and serum lipids: A meta-analysis of randomized controlled clinical trials. Analysis of the content of the diterpenes cafestol and kahweol in coffee brews. Coffee consumption and mortality from all causes, cardiovascular disease, and cancer: A dose-response meta-analysis. K-Cup coffee contains between 75-125 mg of caffeine per 6 fluid ounces. articles/journal-of-alzheimers-disease/jad091525 Unfortunately, there is not a precise answer. Caffeine exposure and the risk of Parkinson's disease: A systematic review and meta-analysis of observational studies. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. It’s also in black tea, green tea, chocolate, energy drinks, and even one type of jerky.
